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原发性肝癌患者TACE术后综合征的危险因素分析

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目的 探讨原发性肝癌经皮肝动脉化疗栓塞(TACE)术后综合征临床表现及相关影响因素.方法 回顾性分析89例原发性肝癌患者的临床资料,均行TACE术治疗,依据是否发生术后综合征分为两组,通过查阅病例资料、电话随访等多种方式收集两组基础资料行Logistic回归分析,获得影响原发性肝癌TACE术后综合征的独立危险因素.结果 89例患者共44例发生术后综合征,发生率为49.44%(44/89);其中恶心呕吐15例(34.09%)、发热8例(18.18%)、肝区疼痛7例(15.91%)、腹胀9例(20.45%)、肝功能损害5例(11.36%);两组年龄、合并肝硬化、碘油剂量、肿瘤大小、Child分级相比,差异有统计学意义(P<0.05);多因素显示,年龄≥60岁、合并肝硬化、碘油剂量≥10 ml、巨块型肿瘤及Child分级B级为影响原发性肝癌TACE术后综合征的高危因素(P<0.05且OR>1).结论 原发性肝癌TACE术后综合征发生风险较高,与年龄≥60岁、合并肝硬化、碘油剂量≥10 ml、巨块型肿瘤及Child分级B级关系密切,还需尽早开展针对性干预,减少术后综合征发生.
Risk Factors Analysis of Post TACE Syndrome in Patients with Primary Liver Cancer
Objective To investigate the clinical manifestations and related factors of syndrome after percutaneous arte-rial chemoembolization(TACE)for primary liver cancer.Methods The clinical data of 89 patients with primary liver cancer were retrospectively analyzed,all of whom were treated with TACE.They were divided into 2 groups according to whether postoper-ative syndrome occurred.The basic data of the 2 groups were collected by consulting case data and telephone follow-up for Logistic regression analysis,and the independent risk factors affecting postoperative syndrome of primary liver cancer were obtained.Re-sults A total of 44 of 89 patients developed postoperative syndrome(49.44%(44/89)).There were 15 cases of nausea and vomiting(34.09%),8 cases of fever(18.18%),7 cases of hepatic pain(15.91%),9 cases of abdominal distension(20.45%),and 5 cases of liver function impairment(11.36%).There were significant differences in age,cirrhosis,iodide dose,tumor size and Child grade between the 2 groups(P<0.05).Multiple factors showed that age ≥60 years old,cirrhosis,iodide dose ≥10 ml,massive tumor and Child grade B were high risk factors for TACE postoperative syndrome of primary liver cancer(P<0.05 and OR>1).Conclusion The risk of syndrome after TACE surgery for primary liver cancer is high,which is closely related to age ≥60 years,cirrhosis,iodide dose ≥10 ml,massive tumor and Child grade B.Targeted intervention should be carried out as soon as possible to reduce the incidence of postoperative syndrome.

Primary liver cancerPercutaneous hepatic artery chemoembolizationPostoperative syndromeClinical mani-festationsInfluence factor

胡艳艳

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450000 河南省郑州市第三人民医院

原发性肝癌 经皮肝动脉化疗栓塞 术后综合征 临床表现 影响因素

2024

实用癌症杂志
江西省肿瘤医院 江西省肿瘤研究所

实用癌症杂志

影响因子:1.241
ISSN:1001-5930
年,卷(期):2024.39(10)