Correlation of MRI-DWI Parameters with CA125 and CA153 Expression in Breast Cancer and Their Diagnostic Value
Objective To investigate the correlation of magnetic resonance diffusion imaging-diffusion weighted imaging(MRI-DWI)parameters with carbohydrate antigen 125(CA125)and CA153 expression in breast cancer,and to evaluate their di-agnostic value.Methods 88 patients with suspected breast cancer were enrolled.MRI-DWI examination and dynamic contrast scan along with the detection of CA125 and CA153 were performed in all patients.Taking pathological results as the gold stand-ard,the positive diagnostic rate of MRI-DWI was analyzed,and the MRI-DWI parameters,serum levels of CA125 and CA153 were compared between positive and negative patients.The correlation of MRI-DWI parameters with CA125 and CA153 expressions was discussed,thereafter,the value of MRI-DWI,serum CA125 and CA153 in the diagnosis of breast cancer was evaluated.Results Receiver Operating Characteristic(ROC)curve showed that DWI had the highest diagnostic value for breast cancer when the b-value was 800 s/mm2.Early enhancement,peak enhancement,serum CA125 and CA153 levels of positive group were significantly higher than those of negative group,and the apparent coefficient diffusion(ADC)values at b values of 800 s/mm2 of positive group were obviously lower than those of negative group.The result of spearman showed that early enhancement rate and peak en-hancement rate were positively correlated with serum CA125 and CA153 levels,and the ADC values of DWI at b values were neg-atively correlated with the serum CA125 and CA153 levels in breast cancer patients(P＜0.05).Analysis found that DWI had the highest diagnostic value for breast cancer when the b-value was 800 s/mm2(AUC=0.823).In the diagnosis of breast cancer,the sensitivity and specificity were 81.0％and 55.6％under MRI-DWI curve,those were 77.7％and 75.9％under CA125 curve,and were 66.7％and 79.7％under CA153 curve,while the combined detection of MRI-DWI parameters with CA125 and CA153 expression showed sensitivity and specificity of 88.9％and 86.1％,indicating that the diagnostic value of MRI-DWI combined with serum CA125 and CA153 levels was better than the separate examination(P＜0.05).Conclusion MRI-DWI parameters are closely related to the serum expression of CA125 and CA153 in breast cancer patients,the sensitivity and specificity of com-bined tests are better than those of separate test,which is of great diagnostic value.
万方数据
维普
