Effects of Laparoscopic Nephron Sparing Nephrectomy on Surgical Related Indexes,Re-nal Function and Hematology Indexes in Patients with Renal Cell Carcinoma
Objective To investigate the effect of laparoscopic nephron sparing nephrectomy(RPNSS)in the treatment of renal cell carcinoma.Methods 80 patients with renal cell carcinoma were selected and randomly divided into 2 groups,with 40 patients in each group.The control group received laparoscopic radical nephrectomy(LRN)treatment,while the observation group received RPNSS treatment.The operation related indexes,renal function indexes,Hematology indexes and complications were compared between the 2 groups.Results The intraoperative bleeding volume in the observation group was(175.62±15.43)ml,which was higher than that in the control group(98.65±7.52)ml,and the surgical time and hospital stay were(105.63±10.28)minutes and(11.86±1.42)days,which were longer than those in the control group(90.15±7.46)minutes and(9.87±1.32)days,with statistical significance(P＜0.05);The levels of serum creatinine(Scr),Blood urea nitrogen(BUN)and 24h urinary protein in the observation group were(92.52±9.26)μMol/L,(8.04±1.18)mmol/L,(0.28±0.05)g,lower than the control group's(108.22±10.34)µ Mol/L,(9.67±1.24)mmol/L,(0.36±0.08)g,the difference was statistically sig-nificant(P＜0.05);The postoperative levels of cortisol(COR)and Vascular endothelial growth factor(VEGF)in the observation group were(13.12±1.34)ng/L,(118.69±10.35)ng/L,lower than those in the control group(16.05±1.42)ng/L,(134.87±13.45)ng/L,with statistical significance(P＜0.05);There was no statistically significant difference in complications between the two groups(P＞0.05).Conclusion RPNSS can better preserve the patients renal function in the treatment of renal cell carcino-ma,but the long surgical time and high intraoperative bleeding require comprehensive clinical consideration and careful selection.
Renal cell carcinomaLaparoscopic nephron sparing nephrectomyRenal functionHematology index
维普
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