Clinical Effect of Compound Sophora Flavescens Injection Combined with Duloxetine on Cancer Pain of Advanced Pancreatic Cancer Patients
Objective To observe the impacts of compound Kushen injection combined with duloxetine on visual ana-logue scale(VAS)score and pain mediator levels in patients with pancreatic ductal adenocarcinoma(PDAC)pain.Methods 96 patients with advanced PDAC pain who were treated were collected and randomly grouped into the test group(compound Kushen injection+duloxetine)and the control group(duloxetine),with 48 cases in each group.The clinical efficacy,VAS score,pain me-diators[P substance(SP),5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2)]and quality of life[Quality of Life Question-naire-Core 30(QLQ-C30)]of the 2 groups were compared.Results The total effective rate of the experimental group after treat-ment was obviously higher than that of the control group(P＜0.05);the VAS score of the experimental group was obviously lower than that of the control group after 2 and 4 weeks of treatment.The levels of serum SP,5-HT,and PGE2 in the experimental group were obviously lower than those in the control group at 2 and 4 weeks after treatment.After 4 weeks of treatment,the QLQ-C30 score in the experimental group was obviously higher than that in the control group.Conclusion Compound Kushen injection combined with duloxetine can effectively reduce the VAS score and the pain mediator levels in patients with advanced PDAC pain,thus improving the quality of life of patients.
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