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非肌层浸润性膀胱癌患者术后膀胱痉挛发生的危险因素

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目的 探讨非肌层浸润性膀胱癌患者术后膀胱痉挛发生的危险因素,为临床防治膀胱痉挛提供依据.方法 回顾性分析经尿道膀胱肿瘤切除术治疗的96例非肌层浸润性膀胱癌患者临床资料,根据是否发生膀胱痉挛分为痉挛组、未痉挛组.收集2组患者性别、年龄、肿瘤分期、肿瘤数目、留置尿管时间等资料,先进行单因素分析,之后将具有统计学差异的变量纳入多因素Logistic回归模型,最终获取非肌层浸润性膀胱癌患者术后膀胱痉挛发生的危险因素.结果 术后3 d,96例非肌层浸润性膀胱癌患者中,共有30例发生膀胱痉挛,占比为31.25%(30/96);其中轻度痉挛16例,中度痉挛8例,重度6例.痉挛组多发肿瘤、术前尿路感染、尿管留置时间>7 d、膀胱逼尿肌不稳定、术前焦虑患者占比均高于未痉挛组,差异有统计学意义(P<0.05).多因素Logistic回归分析显示,多发肿瘤、术前尿路感染、留置尿管时间>7 d、逼尿肌不稳定、术前焦虑是非肌层浸润性膀胱癌患者术后膀胱痉挛发生的危险因素(OR>1,P<0.05).结论 多发肿瘤、术前尿路感染、尿管留置时间>7 d、逼尿肌不稳定、术前焦虑是非肌层浸润性膀胱癌患者术后膀胱痉挛发生的危险因素,临床应加强对上述因素的重视并进行针对性干预,以达到预防或减少膀胱痉挛发生的目的.
Risk Factors of Postoperative Bladder Spasm in Patients with Non Muscle Invasive Bladder Cancer
Objective To explore the risk factors of postoperative bladder spasm in patients with non muscle invasive bladder cancer,and provide basis for clinical prevention and treatment of bladder spasm.Methods The clinical data of 96 pa-tients with non muscle invasive bladder cancer who underwent transurethral resection of bladder tumor were retrospectively ana-lyzed.They were divided into spasticity group and non spasticity group according to whether bladder spasm occurred.The data such as gender,age,tumor stage,number of tumors,duration of indwelling catheter,etc.of the 2 groups of patients were collected,and the single factor analysis was performed first.Then the variables with statistical differences were included in the multivariate Logistic regression model,and finally the risk factors of bladder spasm in patients with non muscle invasive bladder cancer after surgery were obtained.Results Three days after operation,30 of 96 patients with non muscle invasive bladder cancer developed bladder spasm,accounting for 31.25%(30/96).Among them,there were 16 mild spasms,8 moderate spasms,and 6 severe spasms.The patients with multiple tumors,preoperative urinary tract infection,catheter retention time>7 days,bladder Detrusor muscle instability,and preoperative anxiety in the spasticity group were higher than those in the non spasticity group,with a statis-tical significant difference(P<0.05).Multivariate Logistic regression analysis showed that multiple tumors,preoperative urinary tract infection,indwelling catheter time>7d,detrusor instability,preoperative anxiety were risk factors for postoperative bladder spasm in patients with non muscle invasive bladder cancer(OR>1,P<0.05).Conclusion Multiple tumors,preoperative urina-ry tract infection,catheter retention time>7 days,detrusor muscle instability,and preoperative anxiety are risk factors for postop-erative bladder spasm in patients with non muscle invasive bladder cancer.Clinical attention should be paid to these factors and targeted intervention should be carried out to prevent or reduce the occurrence of bladder spasm.

Non muscle invasive bladder cancerBladder spasmsTransurethral resection of bladder tumorsRisk factors

吴培、董亚娟、李思思

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450000 郑州大学第一附属医院

非肌层浸润性膀胱癌 膀胱痉挛 经尿道膀胱肿瘤切除术 危险因素

2020年河南省医学科技攻关计划联合共建项目

LHGJ20200273

2024

实用癌症杂志
江西省肿瘤医院 江西省肿瘤研究所

实用癌症杂志

影响因子:1.241
ISSN:1001-5930
年,卷(期):2024.39(10)