Expression and Prognostic Significance of DJ-1 and sMICA in Serum of Patients with Non-small Cell Lung Cancer
Objective To investigate the expression and clinical prognosis of DJ-1 and sMICA in serum of patients with non-small cell lung cancer.Methods 202 patients with non-small cell lung cancer were selected to be included in the observa-tion group,40 patients with benign lung lesions were selected to be included in group A,and 30 healthy persons were selected to be included in group B.The patients were divided into survival group(n=190)and death group(n=12).Serum DJ-1 and sMICA levels were detected by enzyme-linked immunosorbent assay(ELISA),and the serum DJ-1 and sMICA levels in the 3 groups were statistically measured.The relationship between serum DJ-1 and sMICA levels and clinicopathological features in the observation group was analyzed.COX regression was used to analyze the prognostic factors of patients.Results There were significant differ-ences in serum DJ-1 and sMICA levels among 3 groups(P＜0.05).The levels of serum DJ-1 and sMICA in the observation group were higher than those in group A and group B(P＜0.05),but there was no statistical significance between group A and group B(P＞0.05).Serum DJ-1 and sMICA levels in NSCLC patients with TNM stage Ⅲ to Ⅳ were higher than those in stage Ⅰ to Ⅱ,and serum DJ-1 and Smica levels in patients with lymph node metastasis were higher than those without lymph node metastasis(P＜0.05).Serum DJ-1 and Smica levels in death group were higher than those in survival group,P＜0.05.The increase of serum DJ-1 level,Smica level,lymph node metastasis and Ⅲ～Ⅳ stage were the risk factors affecting the prognosis of patients(P＜0.05).Conclusion The expression levels of serum DJ-1 and Smica in NSCLC patients are closely related to clinicopathological features.The increase of serum DJ-1 and Smica levels,lymph node metastasis and prognosis risk factors of stage Ⅲ～Ⅳ nsclc patients.
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