摘要
目的 探讨CD133、CD44 在肺癌组织中的表达及与临床病理特征间的关系.方法 选取80 例肺癌患者,均行手术治疗,术中采集肿瘤组织及癌旁正常组织,开展免疫组化染色法,统计CD133、CD44 在肿瘤组织及癌旁正常组织内的表达情况,并分析CD133、CD44 表达与年龄、淋巴结转移、肿瘤直径、TNM 分期间的关系.结果 肿瘤组织内CD133、CD44 阳性率为63.25%、68.75%,高于癌旁正常组织的 7.50%、11.25%(P＜0.05);CD133 阳性组中淋巴结转移、肿瘤直径≥3 cm、TNM分期Ⅲ期的患者占比为33.96%、56.60%、35.85%,高于阴性组的3.70%、29.63%、7.41%(P＜0.05);CD44 阳性组中淋巴结转移、肿瘤直径≥3 cm、TNM分期Ⅲ期的患者占比为 32.73%、56.36%、36.36%,高于阴性组的4.00%、28.00%、4.00%(P＜0.05).结论 CD133、CD44 在肺癌组织中存在较高阳性表达,且与淋巴结转移、肿瘤直径及分期关系密切,或可为临床治疗提供参考.
Abstract
Objective To explore the expression of CD133 and CD44 in lung cancer tissue and their relationship with clinical pathological features.Methods 80 lung cancer patients were selected,all of whom underwent surgical treatment.Tumor tissue and adjacent normal tissue were collected during surgery for examination.Immunohistochemical staining was performed to statistically analyze the expression of CD133 and CD44 in tumor tissue and adjacent normal tissue.The relationship between CD133 and CD44 expression and age,lymph node metastasis,tumor diameter,and TNM staging was analyzed.Results The posi-tive rates of CD133 and CD44 in tumor tissues were63.25%and68.75%,which were higher than those in normal tissues adja-cent to cancer at 7.50%and 11.25%(P＜0.05);The proportion of lymph node metastasis,tumor diameter≥3 cm,and TNM stage Ⅲ in the CD133 positive group was 33.96%,56.60%,and 35.85%,which was higher than the negative group's 3.70%,29.63%,and 7.41%(P＜0.05);The proportion of lymph node metastasis,tumor diameter≥3 cm,and TNM stage Ⅲ in the CD44 positive group was 32.73%,56.36%,and 36.36%,which was higher than the negative group's 4.00%,28.00%,and 4.00%(P＜0.05).Conclusion CD133 and CD44 have high positive expression in lung cancer tissue and are closely related to lymph node metastasis,tumor diameter,and staging,which may provide new directions for clinical treatment.
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