The Expression of CD133 and CD44 in Lung Cancer Tissue and Their Correlation with Clinical Pathological Characteristics
Objective To explore the expression of CD133 and CD44 in lung cancer tissue and their relationship with clinical pathological features.Methods 80 lung cancer patients were selected,all of whom underwent surgical treatment.Tumor tissue and adjacent normal tissue were collected during surgery for examination.Immunohistochemical staining was performed to statistically analyze the expression of CD133 and CD44 in tumor tissue and adjacent normal tissue.The relationship between CD133 and CD44 expression and age,lymph node metastasis,tumor diameter,and TNM staging was analyzed.Results The posi-tive rates of CD133 and CD44 in tumor tissues were63.25%and68.75%,which were higher than those in normal tissues adja-cent to cancer at 7.50%and 11.25%(P＜0.05);The proportion of lymph node metastasis,tumor diameter≥3 cm,and TNM stage Ⅲ in the CD133 positive group was 33.96%,56.60%,and 35.85%,which was higher than the negative group's 3.70%,29.63%,and 7.41%(P＜0.05);The proportion of lymph node metastasis,tumor diameter≥3 cm,and TNM stage Ⅲ in the CD44 positive group was 32.73%,56.36%,and 36.36%,which was higher than the negative group's 4.00%,28.00%,and 4.00%(P＜0.05).Conclusion CD133 and CD44 have high positive expression in lung cancer tissue and are closely related to lymph node metastasis,tumor diameter,and staging,which may provide new directions for clinical treatment.
Lung cancerCD133CD44Clinical expressionPathological features
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