Expression of Serum NSE,CYFRA21-1,Pro-GRP in Lung Cancer Patients and Their Re-lationship with Clinical Pathological Characteristics
Objective To investigate the expression of serum neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1),and gastrin releasing peptide precursor(Pro-GRP)in lung cancer patients and their relationship with clinical and pathological characteristics.Methods 88 lung cancer patients were selected and assigned to the malignant group,50 patients with benign lung diseases were assigned to the benign group,and 50 healthy individuals were assigned to the control group.Collect 5ml of fasting elbow median vein blood from the 3 groups of subjects,centrifuge the supernatant,and detect NSE,CYFRA21-1,and Pro-GRP.Compared the differences in NSE,CYFRA21-1,and Pro-GRP levels among the 3 groups,and analyzed the clinical pathological characteristics of lung cancer patients with NSE,CYFRA21-1,and Pro-GRP levels.Results NSE,CYFRA21-1,and Pro-GRP levels in the malignant group were higher than those in the benign group and control group,and levels of various indica-tors in the benign group were higher than those in the control group,with statistical differences(P＜0.05).NSE,CYFRA21-1,and Pro-GRP levels in patients with TNM staging Ⅲ～Ⅳ,low to medium differentiation,and lymph node metastasis were higher than those in patients with stage Ⅰ～Ⅱ,high differentiation,and no lymph node metastasis,with statistical differences(P＜0.05);There was no statistically significant difference in NSE,CYFRA21-1,and Pro-GRP levels among lung cancer patients with differ-ent pathological types and tumor diameters(P＞0.05).T NSE,CYFRA21-1,and Pro-GRP levels were positively correlated with TNM staging and lymph node metastasis in lung cancer patients(P＜0.05),and negatively correlated with the degree of differen-tiation(P＜0.05).Conclusion Serum NSE,CYFRA21-1,and Pro-GRP levels in lung cancer patients are abnormally elevated,and their levels are closely related to TNM staging,differentiation,and lymph node metastasis.
Lung cancerNeuron specific enolaseGastrin releasing peptide precursorCytokeratin 19 fragmentClinical pathological features
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