Expression and Clinical Significance of Combined Detection of Serum CEA,SCC,and CA724 in Serum of Esophageal Cancer Patients
Objective To explore the expression and clinical significance of serum carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),and carbohydrate antigen 724(CA724)combined detection in esophageal cancer(EC).Methods 105 patients with EC who were going to receive surgery were selected as the observation group,and 105 healthy people were selected as the control group.The expression levels of serum CEA,SCC and CA724 in the 2 groups were detected.The rela-tionship between serum CEA,SCC,CA724 and the clinical characteristics of patients with esophageal cancer was analyzed,and the patients were followed up for 1 year after operation.The prognosis of patients was counted,and the predictive value of combined detection of the above indicators for the prognosis of patients with EC was analyzed.Results The serum levels of CEA,SCC,and CA724 in the observation group were higher than those in the control group(P＜0.05).Serum CEA,SCC and CA724 in EC pa-tients were related to clinical stage,differentiation degree,tumor diameter and lymph node metastasis(P＜0.05).All105 EC pa-tients completed 1-year follow-up,of which 38 had poor prognosis.The AUC of serum CEA,SCC and CA724 in predicting the prognosis of EC patients was＞0.7.Conclusion The levels of serum CEA,SCC and CA724 were higher in EC patients,and the combined detection had a high predictive value for the prognosis of EC patients.
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