Objective To investigate the effects of progesterone,radical hysterectomy and bilateral adnexectomy on tumor markers and quality of life in patients with endometrial cancer.Methods A total of 81 patients with endometrial carcinoma were selected,and 37 patients with radical hysterectomy and bilateral adnexectomy were selected as the control group,and 44 pa-tients with progesterone and radical hysterectomy and bilateral adnexectomy were selected as the observation group.The therapeu-tic effect,tumor marker level,quality of life score and adverse reactions were compared between the 2 groups.Results The effec-tive rate of the observation group(93.18%)was higher than that of the control group(75.68%),and the difference was statisti-cally significant(χ2=4.881,P=0.027).Before treatment,there were no significant differences in HE4 and CEA levels between the 2 groups(P＞0.05),but after treatment,HE4 and CEA levels were significantly decreased between the 2 groups(P＜0.05),and the observation group was lower than the control group(P＜0.05).Before treatment,there was no statistical difference in QOL score between the 2 groups(P＞0.05),but after treatment,QOL score between the2 groups was significantly improved(P＜0.05),and the observation group was higher than the control group(t=3.972,P=0.000).The total incidence of adverse reac-tions in the observation group(4.55%)was lower than that in the control group(21.62%),and the difference was statistically significant(χ2=3.953,P=0.047).Conclusion Progesterone,radical hysterectomy and bilateral adnexectomy can improve the treatment effect of endometrial cancer,reduce the level of tumor markers,improve the quality of life of patients,and reduce the in-cidence of adverse events.
ProgesteroneRadical hysterectomyBilateral adnexectomyEndometrial cancerTumor markersQuality of life
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