摘要
目的 探讨三维适形放疗联合89 SrCl2 对前列腺癌骨转移患者的治疗效果.方法 选择前列腺癌骨转移患者(骨转移部位为脊柱/骨盆)60 例为对象,信封法分为两组,各30 例.对照组采用三维适形放疗,观察组联合89 SrCl2治疗,两组均完成 3 个月治疗,比较两组有效率、视觉模拟疼痛(VAS)、Karnofsky活动状态评分(KPS评分)、白细胞计数、血小板计数、血红蛋白水平、前列腺特异性抗原(PAS)、癌胚抗原(CEA)、I型胶原羧基端肽β特殊序列(β-CTx)、骨转化生化标志物I型前胶原氨基端延长肽(TPINP)、血清睾酮水平及不良反应发生率.结果 观察组治疗3 个月有效率高于对照组(P＜0.05);观察组干预后VAS评分低于对照组(P＜0.05);KPS得分高于对照组(P＜0.05);观察组干预后WBC、PLT及Hb高于对照组(P＜0.05);观察组干预后 PAS、CEA、β-CTx、TPINP 及血清睾酮水平低于对照组(P＜0.05);两组不良反应比较无统计差异(P＞0.05).结论 三维适形放疗联合89 SrCl2 能提高前列腺骨癌转移患者治疗有效率,可减轻前列腺癌骨转移患者疼痛,提高患者生活质量,白细胞、血小板及血红蛋白抑制程度较轻,有助于降低肿瘤标志物水平,且未增加不良反应发生率,值得推广应用.
Abstract
Objective To investigate the efficacy of three-dimensional conformal radiotherapy combined with 89 SrCl2 in the treatment of prostate cancer with bone metastasis.Methods A total of 60 patients with prostate cancer with bone metastasis(spine/pelvis)were selected as subjects,and were divided into 2 groups with 30 cases in each group by envelope method.The control group was treated with three-dimensional conformal radiotherapy,and the observation group was treated with 89 SrCl2.Both groups completed 3 months of treatment.The response rate,visual analogue pain(VAS),Karnofsky activity status score(KPS score),white blood cell count,platelet count,hemoglobin level,prostate-specific antigen(PAS),carcinoembryonic antigen(CEA),carboxy-terminal peptide β special sequence of type I collagen(β-CTX),biochemical marker of bone transformation of type I procollagen were compared between the 2 groups Amino-terminal prolongating peptide(TPINP),serum testosterone level and incidence of adverse reactions.Results The effective rate of the observation group was higher than that of the control group(P＜0.05).VAS score of the observation group was lower than that of the control group after intervention(P＜0.05).KPS score was higher than the control group(P＜0.05);After intervention,WBC,PLT and Hb in the observation group were higher than those in the control group(P＜0.05).After intervention,PAS,CEA,β-CTx,TPINP and serum testosterone in the observation group were lower than those in the control group(P＜0.05).There was no statistical difference in toxic and adverse reactions be-tween the 2 groups(P＞0.05).Conclusion Three-dimensional conformal radiotherapy combined with 89 SrCl2 can improve the effective rate of patients with prostate bone cancer metastasis,reduce the pain of patients with prostate bone cancer metastasis,im-prove the quality of life of patients with prostate bone cancer metastasis.The degree of leukocyte,platelet and hemoglobin inhibi-tion is less,helps to reduce the level of tumor markers,and does not increase the incidence of adverse reactions,which is worthy of promotion and application.
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