The Effect of EGFR-TKI Targeted Therapy Combined with Traditional Chemotherapy on Serum Tumor Markers and Immune Function Indicators in Elderly Patients with Ad-vanced Lung Cancer
Objective To investigate the effects of epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)targeted therapy combined with traditional chemotherapy on serum tumor markers and immune function indexes in elderly pa-tients with advanced lung cancer.Methods 74 elderly patients with advanced lung cancer were selected and divided into the ob-servation group(n=37)and the control group(n=37)by random number table.The control group was treated with traditional chemotherapy,and the observation group was treated with EGFR-TKI targeted therapy.The short-term efficacy,serum tumor mark-ers,immune function and adverse reactions were compared between the 2 groups.Results Compared with the control group,the observation group had better short-term efficacy and less adverse reactions,the difference was statistically significant(P＜0.05).Compared with the control group,CD3+,CD4+,CD4+/CD8+were higher in the observation group after treatment,and tumor markers and CD8+were lower,with statistical significance(P＜0.05).Conclusion In elderly patients with advanced lung canc-er,EGFR-TKI targeting therapy on the basis of traditional chemotherapy can improve the short-term efficacy,improve immune function,reduce the level of tumor markers,and have fewer adverse reactions,which is worthy of clinical wide application.
Advanced senile lung cancerEGFR-TKI targeted therapyTraditional chemotherapyTumor markersIm-mune function
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