早期连续性血液净化治疗胃癌术后并发急性肾损伤的临床效果观察
Clinical Observation of Early Continuous Blood Purification Treatment for Gastric Canc-er Complicated with Acute Kidney Injury After Operation
范箫鸳 1宋丽 1王鑫 1王炎1
作者信息
- 1. 450000 郑州大学第一附属医院河医院区
- 折叠
摘要
目的 探讨早期连续性血液净化(CBP)治疗胃癌术后并发急性肾损伤(AKI)的临床效果.方法 按照随机数字表法将郑州大学第一附属医院2021 年2 月至2023 年12 月期间收治的胃癌术后并发AKI患者60 例分为研究组(n=30)与参考组(n=30),前者行早期CBP治疗,后者行传统CBP治疗.对比2 组炎症指标、肾功能指标、病情严重程度、住院时间.结果 治疗后2 组白介素-6(IL-6)、白介素-8(IL-8)、C反应蛋白(CRP)水平均低于治疗前,而研究组各项指标水平低于参考组(P＜0.05).治疗后2 组肝型脂肪酸结合蛋白(L-FABP)、尿液中肾损伤分子-1(KIM-1)、尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平均低于治疗前,而研究组各项指标水平低于参考组(P＜0.05).治疗后2 组急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)评分均低于治疗前,而研究组APACHEⅡ评分低于参考组,且住院时间短于参考组(P＜0.05).结论 早期CBP治疗胃癌术后并发AKI可更好地减轻炎症反应,改善肾功能,减轻患者病情,缩短住院时间.
Abstract
Objective To investigate the clinical effect of early continuous blood purification(CBP)in the treatment of postoperative acute kidney injury(AKI)for gastric cancer.Methods According to random number table method,60 gastric canc-er patients with postoperative AKI were divided into the study group(n=30)and reference group(n=30).The former received early CBP treatment,and the latter received traditional CBP treatment.Inflammatory indexes,renal function indexes,severity of disease and length of hospital stay were compared between the 2 groups.Results After treatment,the values of interleukin-6(IL-6),interleukin-8(IL-8)and C-reactive protein(CRP)in the 2 groups were lower than before treatment,while those in the study group were lower than those in the reference group(P＜0.05).After treatment,the values of liver fatty acid-binding protein(L-FABP),renal injury molecule 1(KIM-1)and urine neutrophil gelatinase-associated lipid carrier protein(NGAL)in 2 groups were lower than before treatment,while those in the study group were lower than those in the reference group(P＜0.05).After treat-ment,the acute physiology and chronic health status score Ⅱ(APACHEⅡ)scores of the 2 groups were lower than before treat-ment,while the APACHEⅡscores of the study group were lower than that of the reference group,and the hospital stay was shorter than that of the reference group(P＜0.05).Conclusion Early CBP treatment of gastric cancer complicated with AKI can better reduce inflammatory response,improve renal function,alleviate the disease of patients,shorten the length of hospital stay.
关键词
胃癌/急性肾损伤/肾功能/连续性血液净化/炎症反应Key words
Gastric cancer/Acute kidney injury/Kidney function/Continuous blood purification/Inflammatory response引用本文复制引用
出版年
2024
NETL
NSTL
万方数据