侵袭性真菌感染是威胁人类健康的一个重要因素，近年来易感人群逐年增加，导致人类真菌疾病负担大幅增加。2022年世界卫生组织发布了一份重点真菌病原体清单，以推动全球对真菌感染和抗真菌耐药性的研究和投资。目前抗真菌药物仍是真菌感染的治疗选择，但是抗真菌药物的毒副作用及耐药影响了临床疗效，改善受损的宿主免疫反应成为提高抗真菌药物有效性的合理途径。现简述真菌感染的流行病学，总结宿主如何通过启动先天和适应性免疫反应来介导清除真菌，同时讨论支持免疫调节疗法治疗侵袭性真菌感染的前景及临床证据。 Invasive fungal infections play an important factor threatening human health。In recent years， the number of the susceptible population of invasive fungal infections has increased rapidly， leading to a significant increase in the disease burden of human fungi。In 2022， the World Health Organization released a list of key fungal pathogens， aiming to promote global research and investment in fungal infection and antifungal resistance。At present， antifungal drugs are preferred for anti-fungal infection treatment， although the efficacy is limited by the adverse events and drug resistance。Improving the damaged host immune response is a reasonable way to improve the effectiveness of antifungal drugs。This article briefly described the epidemiology of fungal infections， summarized how hosts mediate the clearance of fungi by initiating innate and adaptive immune responses， and discussed the prospects and clinical evidence supporting immunomodulatory therapy for invasive fungal infections。
Immunotherapy for fungal infections
Invasive fungal infections play an important factor threatening human health.In recent years, the number of the susceptible population of invasive fungal infections has increased rapidly, leading to a significant increase in the disease burden of human fungi.In 2022, the World Health Organization released a list of key fungal pathogens, aiming to promote global research and investment in fungal infection and antifungal resistance.At present, antifungal drugs are preferred for anti-fungal infection treatment, although the efficacy is limited by the adverse events and drug resistance.Improving the damaged host immune response is a reasonable way to improve the effectiveness of antifungal drugs.This article briefly described the epidemiology of fungal infections, summarized how hosts mediate the clearance of fungi by initiating innate and adaptive immune responses, and discussed the prospects and clinical evidence supporting immunomodulatory therapy for invasive fungal infections.
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