近年来，2型固有淋巴样细胞(ILC2)的发现拓展了人们对2型免疫的理解，推动了2型炎症概念的诞生。2型炎症是固有免疫和适应性免疫共同介导的炎症反应，主要由ILC2和2型辅助性T细胞参与，其特征为2型细胞因子的上调及IgE介导的炎症介质释放和屏障功能障碍。由于2型炎症这一共同内在机制，患者常出现2型炎症性疾病共存的情况，且其在儿童和青少年中的患病率和严重程度持续上升，给患儿及其家庭带来沉重负担。现总结近年来对2型免疫反应机制认知的拓展及对2型炎症性疾病病理生理机制的新认识，强调ILC2在其中发挥的重要作用，并对部分用于治疗2型炎症的靶向生物制剂进行概括，从而对2型炎症有更系统、全面、深入的了解。 In recent years， the discovery of Group 2 innate lymphoid cells(ILC2) has expanded the understanding of type 2 immunity and promoted the birth of the concept of type 2 inflammation。Type 2 inflammation is an inflammatory reaction mediated by both innate and adaptive immunity。It is mainly involved by ILC2 cells and T helper 2 cells and is characterized by upregulation of type 2 cytokines and IgE-mediated release of inflammatory mediators and barrier dysfunction。Due to the common intrinsic mechanism， several kinds of type 2 inflammatory diseases always coexist in the same person， and their prevalence rate and severity continue to rise among children and adolescents， placing a heavy burden on them and their families。This review summarizes the recent development in understanding the mechanism of type 2 immune response and the pathophysiological mechanism of type 2 inflammatory diseases， emphasize the importance of ILC2 and summarize some targeted biologics used in the treatment of related diseases， so as to have a more systematic， comprehensive and in-depth understanding of type 2 inflammation。
Type 2 inflammatory diseases: a new pattern of Group 2 innate lymphoid cells-dendritic cells-T helper 2 cells and advances in targeted drug therapies
In recent years, the discovery of Group 2 innate lymphoid cells(ILC2) has expanded the understanding of type 2 immunity and promoted the birth of the concept of type 2 inflammation.Type 2 inflammation is an inflammatory reaction mediated by both innate and adaptive immunity.It is mainly involved by ILC2 cells and T helper 2 cells and is characterized by upregulation of type 2 cytokines and IgE-mediated release of inflammatory mediators and barrier dysfunction.Due to the common intrinsic mechanism, several kinds of type 2 inflammatory diseases always coexist in the same person, and their prevalence rate and severity continue to rise among children and adolescents, placing a heavy burden on them and their families.This review summarizes the recent development in understanding the mechanism of type 2 immune response and the pathophysiological mechanism of type 2 inflammatory diseases, emphasize the importance of ILC2 and summarize some targeted biologics used in the treatment of related diseases, so as to have a more systematic, comprehensive and in-depth understanding of type 2 inflammation.
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