抽动障碍实验动物研究进展
Research progress in animal models for tic disorder
柯钟灵 1陈燕惠1
作者信息
- 1. 福建医科大学附属协和医院儿科,福州 350000
- 折叠
摘要
抽动障碍是儿童期起病的神经发育障碍性疾病,其特征为不自主的运动或发声抽动,可伴多种共患病,可能严重影响患儿的日常生活、学习及社交活动等.对其病因及病理机制的探索以及药物的开发,常常需要在动物模型上进行相关研究.目前存在多种抽动障碍模型的构建方法,包括诱发性及自发性动物模型,如神经递质异常、免疫功能紊乱构建的诱发性动物模型以及基因工程构建的自发性动物模型,尚无一种动物模型能够完全符合抽动障碍的表现.现对抽动障碍常用的动物模型进行总结,以期为抽动障碍的病理机制探索及药物的开发提供动物模型参考.
Abstract
Tic disorder(TD)is a neurodevelopmental disorder that occurs in childhood,characterized by involuntary movements or vocal tics and occasionally accompanied by various comorbidities.It may seriously affect children's daily life,learning and social activities.Exploring its etiology and pathological mechanisms and developing drugs require extensive research on animal models.There are currently various methods for constructing TD models,including induced and spontaneous animal models,such as induced animal models with abnormal neurotransmitters and immune functions and spontaneous animal models based on genetic engineering.However,no animal model can fully match the manifestations of TD.This article summarizes the commonly used animal models for TD to provide references for exploring pathological mechanisms and developing drugs.
关键词
动物模型/抽动障碍/病因/发病机制Key words
Animal model/Tic disorder/Cause/Pathogenesis引用本文复制引用
基金项目
福建省自然科学基金(2023J05041)
出版年
2024
NETL
NSTL
万方数据