摘要
抽动障碍是一种起病于儿童时期,以抽动为主要临床表现的神经发育障碍性疾病,为一组原因不明的运动障碍.目前还未确定抽动障碍的主要致病基因,现就抽动障碍神经递质相关遗传易感基因(DRD2、DRD4、SLC6A4、HDC、ADRA2A)、相关易感基因变异(ASH1L、CELSR3、PNKD、NRXN1,CNTN6)和其他易感基因(FLT3、SLITRK1)3部分进行综述,以期为基于基因变异的精准治疗提供参考.
Abstract
Tic disorder(TD)is a neurodevelopmental disorder that starts in childhood with tics as its primary clinical manifestation.It is a group of movement disorders with unknown causes.At present,the main pathogenic genes of TD have not been identified.In this paper,TD neurotransmitter-associated susceptibility genes(DRD2,DRD4,SLC6A4,HDC,ADRA2A),related susceptibility gene variations(ASH1L,CELSR3,PNKD,NRXN1,CNTN6),and other susceptibility genes(FLT3,SLITRKI)were reviewed to provide references for the precision treatment based on gene variations.
基金项目
国家重点研发计划(2016YFC1306202)
湖北省科技计划立项项目儿童神经发育障碍临床医学研究中心项目(2022DCC020)
NETL
NSTL
万方数据