Clinical characteristics of eosinophilic lung diseases in children
Objective To analyze the clinical characteristics of eosinophilic lung diseases(ELD)in children to enhance pediatricians'understanding of ELD.Methods In this retrospective cross-sectional study,a total of 149 children with ELD were recruited from Beijing Children's Hospital,Capital Medical University between April 1,2007 and March 31,2022.Chi-square test,Fisher's exact test,Mann-Whitney U test and Kruskal-Wallis test were used to analyze data and conclude clinical characteristics.Spearman correlation was used to analyze the correlation between eosinophils in peripheral blood and bronchoalveolar lavage fluid.Chi-square test and Kappa consistency test were used to compare the differences and consistency in diagnostic results between bronchoalveolar lavage fluid or lung biopsy and eosinophil elevation with chest imaging abnormalities.Results(1)The isolated lung involvement was mostly caused by allergic bronchopulmonary aspergillosis(9 patients),and other system involvement by idiopathic hypereosinophilic syndrome(89 patients).(2)The main respiratory manifestations included coughing(90 cases,60.4％)and expectoration(41 cases,27.5％),while 23.5％(35 cases)of patients had no respiratory symptoms;50.3％had digestive system involvement,and 40.9％had skin involvement.These were the two most commonly affected organs.(3)Spearman correlation was performed between eosinophils in peripheral blood and bronchoalveolar lavage fluid(r=0.3,P＜0.05).Chi-square test was performed to compare ELD diagnosed by bronchoalveolar lavage fluid or lung biopsy with peripheral blood eosinophilia accompanied by abnormal chest imaging(P＜0.05).Kappa consistency test(Kappa＜0.2)showed poor consistency between the two diagnostic methods.Conclusions ELD are present in children,and multiple etiologies may be pathogenic.Among children with ELD,the isolated lung involvement is mainly caused by allergic bronchopulmonary aspergillosis.The digestive system and skin are the most commonly affected organs,except for lungs.The correlation between eosinophil levels in peripheral blood and bronchoalveolar lavage fluid is poor.
NETL
NSTL
万方数据
