Research progress of autoimmune glial fibrillary acidic protein astrocytopathy
Autoimmune glial fibrillary acidic protein astrocytopathy(GFAP-A)is a novel autoimmune disease of the central nervous system.The disease can affect any region of the cerebrum,cerebellum,optic nerve,and spinal cord,with encephalitis,meningoencephalitis and encephalomyelitis being the most common.Patients usually present with headache,fever,disturbance of consciousness,autonomic dysfunction,and visual impairment,and the diagnosis is mainly based on positive anti-glial fibrillary acidic protein antibodies in cerebrospinal fluid and serum.The disease is sensitive to glucocorticoids,with 70％of patients responding well to high-dose glucocorticoid pulse therapy and having a good prognosis.About one in five patients have residual nervous system sequelae,requiring long-term immunosuppressive therapy.This paper reviews the etiology,pathogenesis,clinical features,diagnosis and differential diagnosis,treatment and prognosis of GFAP-A by analyzing relevant studies at home and abroad,in order to deepen the understanding of this disease and provide references for its clinical diagnosis and treatment.
Glial fibrillary acidic proteinEncephalitisMyelitisAutoimmune glial fibrillary acidic protein astrocytopathyResearch progress
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