免疫细胞在IgA肾病中的作用研究进展
Research progress on the role of immune cells in IgA nephropathy
周蔚然 1刘雪梅 1董琳琳 1张洪霞1
作者信息
- 1. 山东大学附属儿童医院(济南市儿童医院)肾脏风湿免疫科,济南 250022
- 折叠
摘要
IgA肾病是常见的原发性肾小球疾病,目前发病机制尚不明确.作为一种自身免疫性疾病,免疫应答是发病的关键环节,多种免疫细胞参与IgA肾病的发生发展,固有免疫和适应性免疫的不同细胞亚群直接或间接作用,可导致持续的免疫损伤.现从固有免疫和适应性免疫两个方面阐述免疫细胞在IgA肾病中的作用,旨在为IgA肾病相关研究提供参考.
Abstract
IgA nephropathy is a common primary glomerular disease.Its pathogenesis is currently unclear.As an autoimmune disease,immune response is a key link in the onset of IgA nephropathy.Multiple immune cells are involved in the occurrence and development of IgA nephropathy.The impacts of different cell subpopulations of innate and adaptive immunity can lead to sustained immune damage directly or indirectly.This article elaborates on the role of immune cells in IgA nephropathy from two aspects,namely innate immunity and adaptive immunity,aiming to provide references for further research on IgA nephropathy.
关键词
IgA肾病/巨噬细胞/树突状细胞/B细胞/T细胞Key words
IgA nephropathy/Macrophage/Dendritic cell/B cell/T cell引用本文复制引用
基金项目
山东省学校卫生协会科研项目(SDWS2022157)
济南市卫生健康委科技项目(2022-2-148)
济南市卫生健康委科技项目(2023-2-151)
济南市卫生健康委大数据科技计划(2023-YBD-2-19)
出版年
2024
NETL
NSTL
万方数据