Potential value of L-citrulline in the treatment of persistent pulmonary hypertension of the newborn
Persistent pulmonary hypertension of the newborn(PPHN)is a common and critical disease in the neonatus characterized by persistent pulmonary hypertension and hypoxemia,with a high mortality.Except for intubation and ventilator support,recognized treatments often require the application of pulmonary vasodilators drugs,such as inhaled nitric oxide,Sildenafil,etc,each with its own advantages.In recent years,L-citrulline,as a potential therapeutic option,has shown huge potential in PPHN treatment.The purpose of this review is to explore the possible potential of L-citrulline in the treatment of PPHN in terms of therapeutic mechanism,pharmacokinetics,current status of research and future perspectives.
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