L-瓜氨酸治疗新生儿持续性肺动脉高压的潜在价值
Potential value of L-citrulline in the treatment of persistent pulmonary hypertension of the newborn
杨星月 1钟隽镌 1许芳 1叶秀桢1
作者信息
- 1. 国家临床重点专科建设项目单位/广东省妇幼保健院新生儿科,广东省新生儿重症医学专业质量控制中心,广州 511400
- 折叠
摘要
新生儿持续性肺动脉高压(PPHN)是新生儿期的一种常见急危重症,以持续性肺动脉高压和低氧血症为特征,病死率较高.公认的治疗方法除呼吸机支持有效通气外,还需要应用肺血管扩张药物,如吸入一氧化氮、西地那非等,各有其优势.近年来,L-瓜氨酸作为一种治疗选择,在PPHN治疗中显示出巨大的潜力.本文旨在探讨L-瓜氨酸治疗PPHN方面的可能潜力,从治疗机制、药代动力学、研究现状和未来展望等方面进行综述.
Abstract
Persistent pulmonary hypertension of the newborn(PPHN)is a common and critical disease in the neonatus characterized by persistent pulmonary hypertension and hypoxemia,with a high mortality.Except for intubation and ventilator support,recognized treatments often require the application of pulmonary vasodilators drugs,such as inhaled nitric oxide,Sildenafil,etc,each with its own advantages.In recent years,L-citrulline,as a potential therapeutic option,has shown huge potential in PPHN treatment.The purpose of this review is to explore the possible potential of L-citrulline in the treatment of PPHN in terms of therapeutic mechanism,pharmacokinetics,current status of research and future perspectives.
关键词
婴儿,新生/持续性肺动脉高压/L-瓜氨酸/治疗Key words
Infant,newborn/Persistent pulmonary hypertension/L-citrulline/Treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据