Research progress on the impact of human milk oligosaccharides on immune system development and homeo-stasis in infants
The gut microbiota of infants is crucial for the establishment and development of immune system tolerance and responsiveness,as well as long-term health.Breast milk,as the only recommended source of nutrition for infants under 6 months old,possesses all the necessary nutrients and functional components for their growth,development,and health promotion.Human milk oligosaccharides(HMOs),as distinctive functional components that distinguish human milk from other mammalian milk,possess natural targeting properties to reach the colorectum in its intact form and are essential for the maturation of the gut microbiota,development of the digestive system and maintenance of the immune system function in infants,providing natural protection for the digestive and immune systems of newborns.This article reviews the latest research on how HMOs affect the development of the immune system and homeostasis in infants,and focuses on the mechanism by which HMOs control the gut microbiota and influence the immune system's response through the gut microbiota-immune axis.
Human milkOligosaccharidesInfantsImmune systemEnteric microorganism
NETL
NSTL
万方数据
