Hydrogen energy is a clean,non-polluting,high-energy,and widely used secondary energy source,which is an indispensable part of China's future energy system.Its development and utilization is an important direction of the global energy technology revolution.As a hydrogen energy infrastructure facility,hydrogen refueling station is the key to the whole hydrogen energy industry chain,and accelerating the construction of hydrogen refueling station is of great significance to the development of hydrogen energy.Therefore,this paper firstly combines the hydrogen energy industry chain foundation and relevant hydrogen energy policies to provide reference for the construction layout of hydrogen refueling stations,then comprehensively analyzes the key examination factors for the location of hydrogen refueling stations,and calculates the weight share of each factor using analytic hierarchy process(AHP)hierarchical analysis,and arrives at the conclusion that the profit-and-loss situation accounts for the largest share of the total.It establishes a dynamic prediction model for the profit-and-loss balance of hydrogen refueling stations by combining the calculation of mathematical modeling,gets the breakeven analysis for the optimal site selection through the field research of five refueling/fueling station sites in the Sichuan-Chongqing area,and form a systematic research method of hydrogen station layout and site selection via taking this study as a case to provide important support and reference for relevant enterprises to layout hydrogen station business.