The Expression of Serum CXCL1,CXCL8 And CXCL12 in Elderly Postmenopausal Osteoporosis Patients and Their Predictive Value for Fracture
Objective To investigate the expression of serum CXC chemokine ligand(CXCL)1,CXCL8 and CXCL12 in elderly postmenopausal osteoporosis(PMOP)patients and the value of combined fracture risk assessment tool(FRAX)in predicting fracture occurrence.Methods A retrospective study was conducted on 128 elderly female patients with PMOP admitted to the Bethune International Peace Hospital,the 980th Hospital of Joint Logistics Support Force,Chinese People's Liberation Army,from January 2021 to December 2023.The mean age of the patients was(69.20±6.28)years,ranging from 60 to 86 years.A control group of 50 elderly women with normal physical examination results,aged 60 to 82 years[mean age:(67.40±5.93)years],was also included.The PMOP patients were further categorized into fracture(56 cases)and non-fracture(72 cases)groups,and based on FRAX scores,into high-risk(77 cases)and low-risk(51 cases)groups.Serum levels of CXCL1,CXCL8,and CXCL12 were compared among the groups.Multivariate logistic regression analysis was employed to identify risk factors for fracture in elderly PMOP patients,and a ROC curve was constructed to assess the predictive value of combining CXCL1,CXCL8,CXCL12,and FRAX score for fracture occurrence.Pearson correlation analysis was used to examine the relationship between serum CXCL1,CXCL8,CXCL1 2 levels,and FRAX scores.Results The serum concentrations of CXCL1,CXCL8,and CXCL12 were significantly elevated in both the fracture and non-fracture PMOP groups compared to the control group(P＜0.001).Notably,the levels of these chemokines were significantly higher in the fracture group than in the non-fracture group(P＜0.001).Within the PMOP cohort,patients in the high-risk fracture group had significantly higher serum levels of CXCL1,CXCL8,and CXCL12 than those in the low-risk group(P＜0.001).Multivariate logistic regression analysis revealed that elevated serum levels of CXCL1,CXCL8,and CXCL1 2 were independent risk factors for fracture in elderly PMOP patients.The ROC curve analysis demonstrated that the combination of CXCL1,CXCL8,CXCL1 2,and FRAX score achieved the highest AUC(AUC=0.96,95％CI:0.90～0.99)for predicting fracture in elderly PMOP patients,with a predictive accuracy of 94.15％.Correlation analysis confirmed a positive correlation between serum levels of CXCL1,CXCL8,CXCL12,and FRAX scores in elderly PMOP patients(P＜0.001).Conclusion Elevated serum levels of CXCL1,CXCL8,and CXCL12 are identified as risk factors for fracture in elderly patients with PMOP,and their levels are closely associated with FRAX scores.The integration of CXCL1,CXCL8,CXCL12,and FRAX score provides a highly accurate prediction model for fracture occurrence in elderly PMOP patients.
万方数据
维普
