Advances in the study of Dengue virus and Zika virus cross-antibodies and their effects on antibody-dependent enhancement
The high prevalence of flaviviruses poses many pressing challenges for the world.Dengue virus(DENV)and Zika virus(ZIKV)belong to the Flaviviridae family.Cross-reactive antibodies can be produced after successive infection with both DENV and ZIKV,and antibody-dependent enhancement(ADE)effects occur,which can increase the severity of reinfection and even pose a fatal threat.However,there are currently no novel ZIKV and DENV vaccines available worldwide that eliminate the ADE effect.Therefore,the situation regarding the cross-reactive antibodies to DENV and ZIKV and the mechanism by which they cause ADE are of great interest.Accordingly,we discuss the prevalence and infection mechanism of DENV and ZIKV,and describe the cross-reactivity of antibodies and the mechanism of ADE caused by cross-antibodies to provide new ideas for the future development of these two flavivirus vaccines and the rational design of effective therapeutic drugs.
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维普
