The predictive value of serum interleukin and Toll-like receptor levels for pulmonary infection in elderly patients with chronic obstructive pulmonary disease
Objective To explore the predictive value of serum interleukin(IL)and Toll-like receptor(TLR)levels on pulmonary infection in elderly patients with chronic obstructive pulmonary disease(COPD).Methods Elderly COPD patients admitted to the Department of Respiratory Medicine of Nanyang First People's Hospital from January 2022 to September 2023 were divided into infected group and uninfected group according to the occurrence of pulmonary infection.Serum IL-6,IL-17,TLR4 and TLR7 detection results were collected in 2 groups,and the predictive efficacy of above indexes for pulmonary infection was analyzed by receiver operating characteristic(ROC)curve.The relationship between serum indexes was analyzed by Pearson correlation.P＜0.05 was considered statistically significant.For pairwise comparison,the test level was α=0.017(0.05/3).Results The pulmonary infection rate of COPD patients was 30.00％(45/150),and there were no statistically significant differences between the two groups in gender,age,body mass index,COPD course,history of alcohol consumption,and constituent ratio of combined underlying diseases(all P＞0.05).The proportion of smoking history and COPD grade in the infected group were higher than those in the uninfected group(all P＜0.05).Serum IL-6,IL-17,TLR4 and TLR7 levels in the infected group were higher than those in uninfected group(all P＜0.05).Serum IL-6,TLR4 and TLR7 levels increased with the exacerbation of COPD(all P＜0.05).Serum IL-17 levels in moderate group and severe group were higher than those in mild group(all P＜0.017),and there was no statistically significant difference between the moderate group and severe group(P=0.075).The area under the curve(AUC)of serum IL-6,IL-17,TLR4 and TLR7 to predict pulmonary infection were 0.873,0.879,0.828 and 0.844,respectively.The combined prediction AUC based on Logistic regression was 0.990.Serum IL-6,IL-17,TLR4 and TLR7 were positively correlated in COPD patients(all P＜0.05).Conclusions Serum IL-6,IL-17,TLR4 and TLR7 all have certain predictive value for pulmonary infection in elderly patients with COPD,and the combination of the four can improve the predictive value of pulmonary infection.
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