Spiral tube is the core component of one-through steam generator,so it is very important to study the two-phase flow instability that may occur in the spiral tube to improve the safety and reliability of one-through steam generator.In this paper,the vertical experimental section of spiral tube is used,the inner diameter is 8mm,the spiral diameter is 200mm,the spiral angle is 15°,and the total length is 3091mm.In the test,three typical types of flow instability are found,namely,density wave instability,pressure drop instability and thermal instability.By analyzing the data,the characteristics of flow instability are obtained and the formation mechanism is explained.