Effect of magnetic resonance imaging combined with cerebrospinal fluid lactate dehydrogenase and C-reactive protein detection on clinical diagnosis and treatment of neonatal suppurative meningitis
Effect of magnetic resonance imaging combined with cerebrospinal fluid lactate dehydrogenase and C-reactive protein detection on clinical diagnosis and treatment of neonatal suppurative meningitis
Objective To analyze the effect of magnetic resonance imaging(MRI)combined with cerebrospinal fluid lactate dehydrogenase(LDH)and C-reactive protein(CRP)detection on the clinical diagnosis and treatment of neonatal suppurative meningitis.Methods Totally 30 children with neonatal suppurative meningitis treated in Affiliated Hospital of Putian University from June 2020 to May 2023 were included in observation group,and 30 cases of non-central nervous system infection(including neonatal asphyxia and neonatal hypoxic-ischemic encephalopathy)during the same period were included in control group.All the children underwent MRI examination,and the abnormal rates of the two groups were compared.Receiver operator characteristic(ROC)curve was plotted and the area under ROC curve(AUC)was calculated to evaluate the efficacy of MRI combined with cerebrospinal fluid LDH and CRP in the diagnosis of neonatal suppurative meningitis.Results In observation group,the abnormal rate of MRI was significantly higher than that in control group(100.00%vs.36.67%,P<0.05),and the levels of LDH and CRP in cerebrospinal fluid were significantly higher than those in control group,with statistical significances[LDH(U/L):41.57±4.80 vs.37.55±4.49;CRP(mg/L):7.83±2.49 vs.5.27±1.68;both P<0.05].ROC curve analysis showed that the AUC of MRI,cerebrospinal fluid LDH and CRP in diagnosing neonatal suppurative meningitis was 0.817[95%confidence interval(95%CI)was 0.703-0.931],0.737(95%CI was 0.609-0.866)and 0.793(95%CI was 0.676-0.909),respectively,all of which had certain diagnostic values.The AUC of combined detection of all indicators was 0.843(95%CI was 0.744-0.943),and the diagnostic value was higher than the individual application of each indicator.Conclusion MRI combined with cerebrospinal fluid LDH and CRP has high diagnostic value for neonatal suppurative meningitis,which could effectively guide clinical diagnosis and treatment.
关键词
新生儿化脓性脑膜炎/磁共振成像/脑脊液乳酸脱氢酶/C-反应蛋白
Key words
Neonatal purulent meningitis/Magnetic resonance imaging/Cerebrospinal fluid lactate dehydrogenase/C-reactive protein
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