Objective To investigate the diagnostic value of serum inflammatory indicators combined with blood culture in blood infection.Methods A total of 270 patients with bacterial blood infection who were treated in the Second People's Hospital of Qujing from August 2020 to December 2022 were selected as research objects.All subjects underwent blood culture and were divided into blood culture negative group(170 cases)and positive group(100 cases).Serum interleukin-6(IL-6)was measured by flow cytometry fluorescence luminescence,serum procalcitonin(PCT)was detected by enzyme linked immunofluorescence technology,and whole blood white blood cell count(WBC)was measured by semiconductor laser optical detection and flow cytometry.The differences in above indicators among the groups were compared.The sensitivity,specificity and diagnostic efficacy of different detection methods and combined detection of various indicators were analyzed.The receiver operator characteristic(ROC)curve was drawn,area under ROC curve(AUC)was calculated,and the diagnostic values of IL-6,PCT and WBC combined with blood culture for bloodstream infection were evaluated.Results Compared to blood culture negative group,the levels of IL-6 and PCT in positive group were significantly increased,with statistically significant differences[IL-6(ng/L):330.38(135.07,2 084.30)vs.198.76(89.37,501.98);PCT(μg/L):3.99(0.53,32.64)vs.0.68(0.12,6.95);both P<0.05],and the level of WBC also increased,but the difference was not statistically significant(×109/L:11.11±6.98 vs.9.61±5.78,P>0.05).The AUC of IL-6,PCT,WBC alone and in combination were 0.619,0.664,0.569 and 0.673,respectively.The sensitivity and specificity of combined detection were 44.00%and 82.40%,the specificity of combined detection was higher than those of single indicators.Conclusion The combined detection of IL-6,PCT and WBC could improve the detectable rate in the diagnosis of bloodstream infection,which is more conducive to subsequent treatment.
维普
万方数据