Objective To study the clinical significance of serum amyloid A(SAA)detection in joint fluid on gouty arthritis.Methods A total of 362 patients with gouty arthritis admitted to Quanzhou Orthopedic-Traumatlogical Hospital Affiliated to Fujian Traditional Chinese Medicine University from January 2020 to December 2022 were selected as research objects,and divided into acute gouty arthritis group(66 cases),chronic gouty arthritis acute attack group(189 cases)and chronic gouty arthritis group(107 cases)according to their condition.The joint fluid and blood samples from each group of patients were collected,the levels of SAA were measured using latex enhanced immunoturbidimetry,and the levels of uric acid(UA)were detected using uricase peroxidase method.The differences in the levels of above indicators were compared.The clinical significance of SAA in joint fluid for evaluating the course and activity of gouty arthritis was analyzed using non parametric tests and Spearman correlation analysis.Results The level of joint fluid SAA in acute gouty arthritis group was higher than those in chronic gouty arthritis acute attack group and chronic gouty arthritis group[mg/L:90.15(48.30,174.80)vs.41.30(6.65,124.05),12.83(3.40,37.80),both P<0.05],and the level of SAA in chronic gouty acute attack group was higher than that in chronic gouty arthritis group,with statistical significance(P<0.05).There was no statistically significant difference in the joint fluid UA levels among acute gouty arthritis group,chronic gout acute attack group and chronic gouty arthritis group[μmol/L:497.50(395.50,614.50)vs.531.00(420.00,671.00),536.00(387.00,641.00),both P>0.05].The Spearman correlation analysis results showed that there was no correlation between joint fluid SAA and UA levels(r value was-0.080 and P value was 0.129),but there was a weak correlation between joint fluid SAA and serum SAA levels(r value was 0.493 and P value was 0.006).Conclusion The detection of SAA in joint fluid could serve as an auxiliary diagnostic indicator for active gouty arthritis.
维普
万方数据