摘要
目的 分析妊娠期糖类抗原 125(CA125)与免疫检验结果及部分生化指标的相关性.方法 选择2022年1月—2023年1月在平邑县人民医院接受免疫指标检查的372例产妇作为研究对象,其中免疫检验结果为阳性的 252 例产妇纳入观察组,免疫检验结果正常的 120 例产妇纳入对照组.分析观察组免疫检验结果;采集静脉血检测CA125、肌酐(Cr)、血尿素氮(BUN)及血糖(Glu)水平;采用Pearson相关分析法分析妊娠期CA125与免疫检验指标及部分生化指标的相关性.结果 观察组检出乙肝表面抗原(HBsAg)阳性 126 例纳入HBsAg阳性组,丙肝病毒抗体(anti-HCV)阳性 78 例纳入anti-HCV阳性组,梅毒螺旋体(TP)抗体阳性 48 例纳入TP抗体阳性组,未检出人类免疫缺陷病毒(HIV-1/2)抗体阳性.HBsAg阳性组、anti-HCV阳性组、TP抗体阳性组的CA125 水平均显著高于对照组,Cr、BUN、Glu水平均显著低于对照组[CA125(kU/L):82.97±12.58、74.67±7.87、70.12±5.24比13.57±2.12;Cr(μmol/L):41.98±2.53、44.12±2.47、44.37±2.54、比 53.24±2.64;BUN(mmol/L):2.75±0.42、2.68±0.53、2.74±0.55 比 4.57±1.16;Glu(mmol/L):4.34±1.04、4.21±1.01、4.64±0.94 比 5.12±1.07;均P<0.05].妊娠期CA125 水平变化与HBsAg阳性、anti-HCV阳性、TP抗体阳性、BUN水平均呈正相关(r值分别为0.513、0.462、0.314、0.347,P值分别为0.012、0.017、0.025、0.022).结论 产妇在妊娠期进行CA125 测定并结合免疫测试和部分化指标,可以有效地评价艾滋病、梅毒、乙肝、丙肝等多种疾病的发病风险,促进疾病预防和治疗.
Abstract
Objective To analyze the correlation between carbohydrate antigen 125(CA125)during pregnancy and immune test results and some biochemical indicators.Methods The 372 pregnant women who received immune index tests in Pingyi County People's Hospital from January 2022 to January 2023 were selected as research subjects.The observation group consisted of 252 pregnant women with positive immune test results,and the control group consisted of 120 pregnant women with normal immune test results.The immune test results of observation group of parturients were discussed,the levels of CA125,creatinine(Cr),blood urea nitrogen(BUN)and blood glucose(Glu)in each group were compared,and the correlation between CA125 during pregnancy and immune test indicators and some biochemical indicators was discussed.Results In observation group,126 cases were positive for hepatitis B surface antigen(HBsAg positive group),78 cases were positive for hepatitis C antibody(anti-HCV positive group),48 cases were positive for Treponema pallidum antibody(TP antibody positive group),and no positive human immunodeficiency virus(HIV-1/2)antibody was detected.The CA125 levels in HBsAg positive group,anti-HCV positive group and TP antibody positive group were higher than those in control group,while Cr,BUN and Glu levels were lower than those in control group[CA125(kU/L):82.97±12.58,74.67±7.87,70.12±5.24 vs.13.57±2.12;Cr(μmol/L):41.98±2.53,44.12±2.47,44.37±2.54 vs.53.24±2.64;BUN(mmol/L):2.75±0.42,2.68±0.53,2.74±0.55 vs.4.57±1.16;Glu(mmol/L):4.34±1.04,4.21±1.01,4.64±0.94 vs.5.12±1.07;all P<0.05].The changes in CA125 during pregnancy were positively correlated with HBsAg positivity,anti-HCV positivity,TP antibody positivity and BUN(r values were 0.513,0.462,0.314,0.347,P values were 0.012,0.017,0.025,0.022).Conclusion The determination of CA125 combined with immune test results and biochemical indicators in pregnant women could effectively evaluate the risk of AIDS,syphilis,hepatitis B,hepatitis C and other diseases,and promote prevention and treatment.
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