Objective To investigate the diagnostic value of serological factors combined detection for atherosclerotic cardiovascular disease.Methods The 80 patients with cardiovascular disease admitted to the Third Affiliated Hospital of Xuzhou Medical University from January to December 2023 were selected as research objects,and received carotid artery ultrasonography.The patients with abnormal carotid intima thickness were included in study group(51 cases)and those with normal carotid intima thickness were included in control group(29 cases).Blood samples were collected and the serum levels of homocysteine(HCY),hypersensitive C-reactive protein(hs-CRP)and small and dense low-density lipoprotein cholesterol(sdLDL-C)were measured.Univariate analysis and multivariate Logistic regression analysis were used to explore the risk factors of atherosclerosis in cardiovascular disease.The receiver operator characteristic curve(ROC curve)was established,area under ROC curve(AUC)was calculated,and the predictive efficacy of each index on atherosclerotic cardiovascular disease was analyzed.Results The levels of hs-CRP,HCY and sdLDL-C in study group were higher than those in control group[hs-CRP(mg/L):7.88±2.42 vs.4.42±1.23;HCY(μmol/L):17.53±5.52 vs.10.66±2.56;sdLDL-C(mmol/L):1.36±0.35 vs.0.83±0.22;all P＜0.05].The results of binary Logistic regression analysis showed that the elevated levels of hs-CRP,HCY and sdLDL-C were risk factors for atherosclerosis in patients with cardiovascular disease[odds ratio(OR)were 1.935,1.348 and 6.412,P values were 0.039,0.043 and 0.022].According to Logisitc regression analysis,the prediction model equation was obtained:y=0.660×hs-CRP+0.229×HCY+4.569×sdLDL-C-12.147.Variable data were inserted into the equation,AUC was 0.965,and Youden index,sensitivity and specificity were 0.828,86.27%and 96.55%.Conclusion The elevated levels of serum HCY,hs-CRP and sdLDL-C are all risk factors for atherosclerosis in patients with cardiovascular disease,and the combined detection of the three indexes has high diagnostic value for atherosclerotic cardiovascular disease.
关键词
动脉粥样硬化/小而密低密度脂蛋白胆固醇/同型半胱氨酸/超敏C-反应蛋白
Key words
Atherosclerosis/Small and dense low-density lipoprotein cholesterol/Homocysteine/Hypersensitive C-reactive protein
维普
万方数据