摘要
目的 分析中性粒细胞与淋巴细胞比值(NLR)、凝血四项与妊娠期肝内胆汁淤积症(ICP)病情程度的相关性及检测价值.方法 收集 2023 年 6 月—2024 年 6 月云浮市妇幼保健院产科建档孕妇的临床资料,其中120例ICP孕妇纳入ICP组,根据病情程度分为轻度组(33例)、中度组(56例)、重度组(31例);同期 120 例健康孕妇纳入对照组.检测两组孕妇NLR和凝血四项[包括凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FBG)].比较ICP患者与健康孕妇以及不同病情程度ICP孕妇的上述指标水平差异;采用Pearson相关分析法考察NLR、凝血四项与ICP病情程度的相关性;统计ICP患者各指标阳性率.结果 ICP组孕妇的NLR、FBG水平均显著高于对照组,PT、APTT、TT均显著短于对照组[NLR:4.05±2.36 比 3.42±1.92;FBG(g/L):5.03±0.86 比 3.51±0.65;PT(s):10.76±1.44 比13.41±1.63;APTT(s):28.85±3.30 比 32.07±3.74;TT(s):15.80±1.80 比 16.20±0.80;均P＜0.05].重度ICP患者的NLR、FBG水平均显著高于轻度组和中度组,PT、APTT、TT均显著短于轻度组和中度组,差异均有统计学意义.Pearson相关性分析表明,NLR、FBG均与ICP患者病情程度呈正相关,PT、APTT、TT均与ICP患者的病情程度呈负相关(r值分别为 0.651、0.619、-0.631、-0.672、-0.653,均P＜0.001).ICP患者的NLR、PT、APTT、TT、FBG阳性率分别为 84.17%、89.17%、87.50%、90.83%、91.67%.结论 ICP孕妇的NLR水平较高,且存在凝血功能异常,可结合NLR和凝血四项评估病情程度.
Abstract
Objective To analyze the correlation and detection value of neutrophil to lymphocyte ratio(NLR)and blood clotting four items with the severity of intrahepatic cholestasis of pregnancy(ICP).Methods From June 2023 to June 2024,the clinical data of pregnant women in maternity department of Yunfu Maternal and Child Health Hospital were collected,among them 120 pregnant women with ICP were selected as ICP group.According to severity of condition,they were divided into mild group(33 cases),moderate group(56 cases)and severe group(31 cases),and 120 healthy pregnant women were selected as control group.The levels of NLR and blood clotting four items[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FBG)]were detected.The differences of above indicators between ICP patients and healthy pregnant women,as well as ICP patients with different degrees of illness were compared.Pearson correlation analysis was used to investigate the correlation between NLR and blood clotting four items with the severity of ICP.The positive rates of above indexes in ICP patients were calculated.Results The NLR and FBG levels in ICP group were higher than those in control group,while PT,APTT and TT levels were shorter than those in control group[NLR:4.05±2.36 vs.3.42±1.92;FBG(g/L):5.03±0.86 vs.3.51±0.65;PT(s):10.76±1.44 vs.13.41±1.63;APTT(s):28.85±3.30 vs.32.07±3.74;TT(s):15.80±1.80 vs.16.20±0.80;all P＜0.05].The NLR and FBG levels of severe group were higher than those of mild and moderate ICP groups,while PT,APTT and TT levels were shorter than those of mild and moderate groups,with significant differences.The Pearson correlation analysis showed that NLR and FBG were positively correlated with the severity of ICP,while PT,APTT and TT were negatively correlated with the severity of ICP(r values were 0.651,0.619,-0.631,-0.672,-0.653,all P＜0.001).The positive rates of NLR,PT,APTT,TT and FBG in ICP patients were 84.17%,89.17%,87.50%,90.83%and 91.67%,respectively.Conclusion Pregnant women with ICP have higher levels of NLR and abnormal coagulation function,which could be combined with NLR and coagulation to evaluate the severity of the condition.
基金项目
广东省云浮市医药卫生类科技计划项目(WS2023031002)
维普
万方数据