摘要
目的 探讨血清炎症指标对前列腺增生(BPH)患者下尿路症状进展的潜在影响.方法 选择鄂尔多斯市中医医院 2022 年 1 月—2023 年 1 月收治的 120 例BPH患者纳入研究组,另外选择该院同期120例健康男性体检者纳入对照组.所有患者均进行血清生化指标检测[超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)],测量并记录前列腺总体积及国际前列腺症状评分(IPSS);采用Pearson相关分析法考察hs-CRP、IL-6、PCT与前列腺体积、IPSS评分的相关性.结果 研究组hs-CRP、IL-6、PCT水平、前列腺体积以及IPSS评分均显著高于对照组[hs-CRP(mg/L):12.33±1.37 比 2.08±0.20;IL-6(ng/L):135.86±11.21比6.13±1.46;PCT(μg/L):0.59±0.39比0.03±0.01;前列腺总体积(mL):44.59±8.77比24.08±5.23;IPSS评分(分):18.53±5.12比12.02±2.97;均P＜0.05].Pearson相关性分析结果表明,hs-CRP、IL-6、PCT与前列腺总体积和前列腺IPSS评分均呈正相关(前列腺总体积:r值分别为 0.525、0.438、0.511,P值分别为0.013、0.028、0.020;前列腺IPSS评分:r值分别为0.356、0.428、0.522,P值分别为0.032、0.030、0.016).结论 IL-6、hs-CRP、PCT与BPH患者的尿路症状严重程度均呈显著正相关,上述指标可能有助于早期鉴别BPH患者下尿路症状的严重程度,为个体化治疗和干预提供了新的可能性.
Abstract
Objective To explore the potential impact of serum inflammatory indexes on the progression of lower urinary tract symptoms in patients with benign prostatic hyperplasia(BPH).Methods The 120 patients diagnosed with BPH admitted in Ordos Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were included in study group.Additionally,120 healthy male patients undergoing physical examination during the same period were selected as control group.All patients were tested for serum biochemical indicators[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and procalcitonin(PCT)],and prostate volume and international prostate symptom score(IPSS)were measured and recorded.The correlation between hs-CRP,IL-6,PCT and prostate volume,IPSS score was assessed using Pearson correlation analysis.Results The levels of hs-CRP,IL-6,PCT,prostate volume and IPSS score in study group were higher than those in control group[hs-CRP(mg/L):12.33±1.37 vs.2.08±0.20;IL-6(ng/L):135.86±11.21 vs.6.13±1.46;PCT(μg/L):0.59±0.39 vs.0.03±0.01;prostate volume(mL):44.59±8.77 vs.24.08±5.23;IPSS score(points):18.53±5.12 vs.12.02±2.97;all P＜0.05].Pearson correlation analysis showed that hs-CRP,IL-6 and PCT were positively correlated with prostate volume and IPSS score(prostate volume:r values were 0.525,0.438 and 0.511,P values were 0.013,0.028 and 0.020;IPSS score:r values were 0.356,0.428 and 0.522,P values were 0.032,0.030 and 0.016).Conclusions There is a significant positive correlation between hs-CRP,IL-6,PCT and the severity of lower urinary tract symptoms in patients with BPH.The markers may help for the early identification of symptoms severity in BPH patients,offering new possibilities for individualized treatment and intervention.
维普
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