Objective To analyze the detection results of blood irregular antibodies of the population in eastern Guangdong,study the distribution frequency of clinically significants blood group antigens of red blood cells in the population in this region,and provide valuable blood reserve reference opinions for blood stations and hospitals in eastern Guangdong.Methods The patients who underwent irregular antibody screening in Shantou Central Hospital from 2012 to 2021 were selected as research subjects,and gel anti-globulin method was used to identify the antibodies in patients with positive irregular antibody screening.Results The 108 cases of specific antibodies were identified among 61 036 patients with antibody screening,including 51 cases of anti-E(accounting for 47.22%),19 cases of anti-D(accounting for 17.59%),10 cases of anti-c(accounting for 9.26%),9 cases of anti-e(accounting for 8.33%),5 cases of anti-C(accounting for 4.63%),4 cases of anti-Lea(accounting for 3.70%),4 cases of anti-Jkb(accounting for 3.70%),3 cases of anti-S(accounting for 2.79%),2 cases of anti-M(accounting for 1.85%)and 1 case of anti-s(accounting for 0.93%).There was a statistically significant difference in the positive rates of irregular antibody screening in different departments.Among them,the positive detectable rate in department of neonatology was the highest,which was 1.88%.The department of obstetrics and gynecology had the highest number of positive cases,with 82 cases detected.The positive rate of irregular antibody in female patients with history of pregnancy was higher than that of patients without history of pregnancy(0.77%vs.0.43%,P＜0.05).The positive rate of irregular antibodies in patients with history of blood transfusion was higher than that in patients without history of blood transfusion(0.60%vs.0.43%,P＜0.05).Conclusions The detectable rate of anti-E in the population in eastern Guangdong is the highest.The positive rates of antibody screening are different in different departments.Moreover,pregnancy history and blood transfusion history are related to the production of irregular antibodies.It is possible to reserve blood in advance for common antibodies and"special"patients and ensure the safety of blood transfusion.
维普
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