Apolipoprotein is the protein part of lipoprotein,which has been clearly divided into five categories(ApoA,ApoB,ApoC,ApoD and ApoE).Due to its relatively small molecular weight,ApoC is easily transferred between high density lipoprotein(HDL)and apolipoproteins,and is an interchangeable apolipoprotein that could regulate plasma levels of triacylglycerol(TG)and cholesterol(CHO).As the most abundant apolipoprotein in the ApoC family,ApoCⅢplays an important regulatory role in the catabolism of triglyceride-rich lipoprotein(TRL),which is closely related to the occurrence of many diseases and deserves clinical attention.This article will discuss the structure and function of ApoCⅢ,its relationship with disease,pathogenesis and drug use.
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