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非编码RNA与银屑病

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银屑病是一种免疫介导的慢性炎症性皮肤病,病因及发病机制涉及遗传、免疫、环境等多种因素.该病以皮肤角质形成细胞过度增殖和异常分化为主要特征.微小RNA(microRNA,miRNA)和长链非编码RNA(long non-coding RNA,lncRNA)均属于非蛋白质编码RNA,广泛参与细胞生命活动和多种人类疾病,在表观遗传水平、转录水平及转录后水平发挥重要的调控功能.近年来研究表明,miRNA和lncRNA与银屑病的发生发展有关.该文将miRNA和lncRNA与银屑病的相关性进行综述.
Non-coding RNA and psoriasis
Psoriasis is a chronic, immune-mediated inflammatory disorder characterized by hyperproliferation and abnormal differentiation of keratinocytes. Multiple factors including heredity, immunology and environment participate in its etiology and pathogenesis. MicroRNA and lncRNA are both non-coding RNA involved in many cellular processes and various diseases. They play an important regulatory role at epigenetic, transcriptional and post-transcriptional level. Recent studies have indicated that microRNA and lncRNA are correlated with the occurrence and development of psoriasis. In this review, the correlations between psoriasis and microRNA as well as lncRNA are summarized separately.

PsoriasisNon coding RNA,miRNANon coding RNA,lncRNA

乔锰、孙青

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250014 济南,山东大学附属千佛山医院皮肤科

250014 济南,山东大学齐鲁医院皮肤科

银屑病 非编码RNA,微小RNA 非编码RNA,长链非编码RNA

2018

实用皮肤病学杂志
中国人民解放军北京军区总医院

实用皮肤病学杂志

CSTPCD
影响因子:0.637
ISSN:1674-1293
年,卷(期):2018.11(5)
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