Characteristics of androgenetic alopecia in reflectance confocal microscopy and their clinical significance
Objective To investigate the characteristic changes of skin lesions among patients with androgenetic alopecia(AGA)in reflectance confocal microscopy(RCM),measure the size of the hair follicular orifice and identify specific imaging indicators associated with androgenetic alopecia.Methods The RCM features and corresponding clinical data were collected from 30 early-stage AGA patients 26 healthy individuals,followed by a comparative analysis.Results The perimeter and diameter of follicular orifice serve as quantitative indicators of its size.In the control group,the perimeter of the follicular orifice was(521.01±144.55)μm,with a diameter of(165.84±46.01)μm;whereas in the AGA group,the perimeter of the follicular orifice was was(410.09±167.68)μm with a diameter of(130.54±53.37)μm,and these differences between two groups were found to be statistically significant.The most common RCM features of the follicular orifice in AGA patients was regular outer contours(92.2％),followed by fuzzy inner contours(59.4％),non-reflective borders(76.6％),follicular plugs(38.9％),and onion ring-like borders(7.8％).The features of perifollicles and surrounding tissues under RCM were ranked by frequency as follows:rimmed dermal papillae(76.7％),inflammatory cell infiltration(73.3％),perifollicular and dermal fiber bundles thickening(46.7％),and dilated blood vessels(33.3％).Conclusion RCM plays a crucial role in the early diagnosis of androgenetic alopecia.
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