白细胞介素-17和白细胞介素-22在大疱性类天疱疮患者皮损及血清中的表达与意义
The expression and significance of IL-17,IL-22 in the skin lesions and serum of patients with bullous pemphigoid
崔瑜 1吴远慧 1胡彩霞 1王文氢 1张燕 1高顺强1
作者信息
- 1. 050000 石家庄,河北医科大学第四医院皮肤科
- 折叠
摘要
目的 检测分析大疱性类天疱疮(BP)患者皮损及血清中白细胞介素(IL)-17和IL-22的表达情况,并探讨其在BP发病机制中的意义.方法 选取41例BP患者皮损组织(BP组)及25名健康人正常皮肤组织(对照组),用免疫组化方法检测IL-17和IL-22的表达情况.采用酶联免疫吸附试验(ELISA)检测27例BP患者血清中IL-17和IL-22的水平,并以25名健康人作为对照.结果 BP组患者皮损中IL-17和IL-22的表达均明显高于对照组,差异有统计学意义(均P＜0.01).且BP组患者皮损组织中IL-17与IL-22的表达呈正相关性.BP组患者血清中IL-17和IL-22的表达水平均高于对照组,差异有统计学意义(均P＜0.01).BP组患者血清中IL-17与IL-22的表达呈正相关性.结论 BP患者血清及皮损IL-17和IL-22的表达水平上调,可能参与BP的发病,且两者可能起协同作用.提示3型固有淋巴细胞(ILC3)可能参与BP的致病过程.
Abstract
Objective To investigate the expression levels of IL-17 and IL-22 in patients with bullous pemphigoid(BP)and explore their significance in the pathogenesis of BP.Methods Using immunohistochemical methods to detect the expression of IL-17 and IL-22 in the skin lesions of 41 BP patients and 25 normal skin tissue(the control group).Additionally,the ELISA method was employed to detect the expression of IL-17 and IL-22 in the serum of 27 BP patients and 25 healthy individuals.Results The expression of IL-17 and IL-22 in the skin lesions of BP patients were significantly higher than that in the control group,with statistically significant differences(P＜0.01).Furthermore,a positive correlation was observed between the expression of IL-17 and IL-22 in the skin lesions of BP patients.The expression levels of IL-17 and IL-22 in the serum of BP patients were also higher than those in the control group,with statistically significant differences(P＜0.01).A positive correlation was found between the expression of IL-17 and IL-22 in the serum of BP patients.Conclusions The expression levels of IL-17 and IL-22 are significantly elevated in both the serum and skin lesions of BP patients,suggesting their potential involvement in the pathogenesis of BP,possibly through a synergistic mechanism.Additionally,innate lymphoid cells 3(ILC3)may also be involved in the pathogenesis of BP.
关键词
类天疱疮,大疱性/白细胞介素-17/白细胞介素-22/固有淋巴细胞Key words
Pemphigoid,bullous/IL-17/IL-22/ILCs引用本文复制引用
基金项目
河北省医学科学研究重点课题(20230941)
出版年
2024
NETL
NSTL
万方数据