The application of reflectance confocal microscopy in efficacy evaluation of vitiligo
Objective To explore the application value of reflectance confocal microscopy(RCM)in efficacy evaluation of vitiligo.Methods A total of 100 skin lesions from 73 patients with vitiligo were included in the study.All skin lesions were treated with monotherapy,including topical corticosteroids(TCS)for 28 lesions,topical vitamin D3 analog(TVDA)for 30 lesions,and topical calcineurin inhibitor(TCI)for 42 lesions.Wood's lamp,Vitiligo Noticeability Scale(VNS),and RCM were used to evaluate the efficacy of three therapeutic methods within a period of 0 to 16 weeks.Results The onset time of three therapeutic methods observed by the RCM was earlier than that observed by the Wood's lamp,and the difference was statistically significant(P＜0.05).The number of effective cases observed by the RCM more than that observed by the Wood's lamp within a period of 0 to 6 weeks(P＜0.05),while no significant difference was found between the RCM and the Wood's lamp within a period of 7 to 16 weeks(P＞0.05).There was no significant difference between the Wood's lamp and the VNS in terms of the number of effective cases within a period of 0 to 16 weeks(PP＞0.05).The sensitivity and specificity of RCM were significantly better than those of VNS(P＜0.05)in early efficacy evaluation,when using the results of Wood's lamp as a reference standard.Conclusion RCM features demonstrate significant value in efficacy evaluation of vitiligo,with high level of sensitivity and specificity.Consequently,they can serve as an objective tool for evaluating the early therapeutic efficacy of vitiligo.
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