Correlation between serum eotaxin-2 and MMP-9 levels and disease severity in patients with bullous pemphigoid
Objective To explore the correlation between serum eosinophilic chemotactic factor-2(eotaxin-2)and matrix metalloproteinase-9(MMP-9)levels and disease severity in patients with bullous pemphigoid.Methods Sixty patients diagnosed with bullous pemphigoid at Cangzhou People's Hospital from January 2021 to January 2023 were selected as the experimental group.Another sixty healthy volunteers from Cangzhou People's Hospital were selected as the control group.All patients in the experimental group were treated with glucocorticoids.The serum levels of eotaxin-2 and MMP-9 in both groups were quantified using enzyme-linked immunosorbent assay(ELISA),while the antibody titers of anti-BP180 and anti-BP230 were determined exclusively in the experimental group.The eosinophil(EOS)counts of patients in the experimental group were detected using flow cytometry.Results Compared to the control group,the serum levels of eotaxin-2 and MMP-9 levels in the experimental group were higher(P＜0.05).Compared to mild cases of bullous pemphigoid,the serum levels of eotaxin-2 and MMP-9 were higher in moderate and severe cases(P＜0.05).Compared to moderate cases,the levels of eotaxin-2 and MMP-9 were higher in severe cases(P＜0.05).Compared to mild cases,the antibody titers of anti-BP180 and anti-BP230,as well as EOS counts,were higher in moderate and severe cases(P＜0.05).Compared to moderate cases,the antibody titers of anti-BP180 and anti-BP230,as well as EOS counts,were higher in severe cases(P＜0.05).The serum levels of eotaxin-2 and MMP-9 showed a positive correlation with BP 180,BP230,and EOS in the experimental group(P＜0.05).In the experimental group,the serum levels of eotaxin-2 and MMP-9 were lower after treatment compared to before treatment(P＜0.05).Conclusion The patients with bullous pemphigoid exhibited higher levels of serum eotaxin-2 and MMP-9,and the levels of both eotaxin-2 and MMP-9 were correlated with disease severity.
NETL
NSTL
万方数据
