Research progress on mechanisms of Cutibacterium acnes inducing acne vulgaris via Th17 inflammatory pathway
Acne vulgaris is a common chronic inflammatory skin disease.The important pathogenic factors of acne vulgaris include high sebum secretion,hyperkeratosis of hair follicles,dysregulation of skin flora and local immune inflammatory reaction.Recent studies on the mechanisms underlying acne occurrence have shown that the biofilm formation of Cutibacterium acnes(C.acnes)is related to increased in vivo virulence factors;The decline in C.acnes diversity led to the dominance of type IA1 C.acnes,subsequently inducing the activation of helper T cells 17(Th17)pathway.In addition,keratinocytes,fibroblasts,monocytes and sebum cells play pivotal roles in the inflammatory response of acne.In this paper,the pathogenesis of acne,triggered by the activation of Th 17 inflammatory pathway induced by C.acnes,was comprehensively reviewed.
NETL
NSTL
万方数据
