Primary cutaneous marginalzone lymphoma:A case report
A 41 year-old man presented with a skin lesion on the upper back for more than half a year,which demonstrated with no pain and itch.Physical examination showed one approximately 1.0 cm in diameter,red,smooth surfaced,slightly-hard nodule around with a focal perilesional,erythematous halo.The histopathology showed the tumor cells were infiltrated diffusely in the dermis,showing more and wider infiltration in the upper part and less and narrow infiltration in the lower part,and with reactive germinal centers,"triphasic"pattern characterized by pale areas in the center(corresponding to germinal centers)surrounded by dark cells of the follicular mantle and by pale neoplastic marginal zone cells,neoplastic cells representing a part of infiltrate and invariably admixed with reactive lymphocytes and with the formation of reactive germinal centers.There were plasma cells,lymphoplasmacytoid cells,marginal zone cells(larger and palercells),small reactive lymphocytes,and occasional large blasts.Immunohistochemistry results showed that CD20,CD79a,MUM-1,Bcl-2 and CD43 were positive,Kappa(plasma cells was negative),Lambda(plasma cells was positive),Ki-67 was 25％,CD3、CD21 and Bcl-6 were negative.Molecular genetics showed that monoclonal gene rearrangement was positive for B-cell lymphoma,T cell monoclonal gene rearrangement was negative.A diagnosis of primary cutaneous margnalzone lymphoma was made.
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