Effects of combining recombinant human basic fibroblast growth factor with vacuum sealing drainage on wound repair and scar formation
Objective To explore the effecst of recombinant human basic fibroblast growth factor(rh-bFGF)combined with vacuum sealing drainage(VSD)on wound repair and scar formation.Methods A total of 104 cases who underwent wound repair from April 2021 to February 2024 were divided into experiment group(n=52)and control group(n=52)according to random number method.The control group was treated with VSD,and the experiment group was treated with rh-bFGF in combination with VSD.The clinical efficacy,wound healing time,total number of dressing changes,number of drain replacements,length of hospital stay,wound healing rate at 14 days post-treatment,and the incidence of adverse reactions were observed and recorded for both groups.Additionally,serum levels of tumor necrosis factor-alpha(TNF-α)and C-reactive protein(CRP)were compared between the two groups before treatment and 14 days after treatment.Furthermore,the vancouver scar scale(VSS)scores were evaluated for both groups three months following the completion of treatment.Results The experimental group demonstrated an effectiveness rate of 96.15％(50/52),significantly higher than the control group's rate of 80.77％(42/52)(P＜0.05).Additionally,the experimental group had significantly shorter wound healing time,fewer dressing changes,fewer drain replacements,and a shorter length of hospital stay compared to the control group(all P＜0.05).At 14 days post-treatment,the wound healing rate in the experimental group was also notably higher than that in the control group(P＜0.05).Three months after treatment,the Vancouver Scar Scale(VSS)score in the experimental group was significantly lower than that in the control group(P＜0.05).At 14 days post-treatment,serum levels of TNF-α and CRP decreased in both groups(all P＜0.05),with the experimental group showing significantly lower levels than the control group(all P＜0.05).The incidence of adverse reactions was 7.69％(4/52)in the experimental group and 15.38％(8/52)in the control group,with no significant difference between the two groups(P＞0.05).Conclusion The combination of rh-bFGF and VSD technology exerts a significant effect on wound repair treatment,effectively reducing both the duration of wound healing and hospitalization while enhancing the wound healing rate,minimizing scar formation,and mitigating inflammation.
ScarReconstructive surgeryRecombinant human basic fibroblast growth factorVacuum sealing drainage
万方数据
维普
