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部分抗肿瘤靶向药物皮肤不良反应及防治研究进展

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随着抗肿瘤靶向药物研发的不断进展,越来越多的靶向药物进入临床,因其靶向性强、疗效可靠和患者耐受性好等优点,目前已广泛用于恶性肿瘤的治疗.然而,在抗肿瘤靶向药物的应用中,也出现了很多不良反应,其中皮肤不良反应最为常见.常见的皮肤不良反应有皮肤瘙痒、干燥、痤疮样皮疹、荨麻疹、甲沟炎、手足反应综合征、口腔黏膜炎和病毒疣等.抗肿瘤靶向药物引起的皮肤不良反应不仅影响患者的生活质量,也影响患者抗肿瘤治疗的依从性.因此,了解抗肿瘤靶向药物引起的皮肤不良反应及应对措施,对应用靶向药物治疗的肿瘤患者具有重要意义.
Advancement in cutaneous adverse reactions to certain targeted anti-tumor drugs
With the continuous advancement in the development of targeted anti-tumor drugs,an increasing number of targeted drugs have been introduced into clinical practice.Due to their high specificity,proven efficacy,and favorable patient tolerance,these drugs have been extensively used in the treatment of malignant tumors.However,the utilization of these drugs has also resulted in a variety of adverse reactions,with skin-related adverse reactions being the most prevalent.Common cutaneous adverse reactions encompass pruritus,dryness,acneiform eruptions,urticaria,paronychia,hand-foot syndrome,oral mucositis,and viral warts.The cutaneous adverse reactions induced by anticancer targeted drugs not only impair the patient's quality of life but also impact adherence to tumor treatment regimens.Consequently,comprehending the cutaneous adverse reactions of targeted anti-tumor drugs and their management is essential for the effective treatment of tumor patients.

Anti-tumor drugs,targetedAdverse drug reactionsLiterature review

祝其辉、吴建华、王玉连

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200082 上海,海军军医大学第一附属医院皮肤科

抗肿瘤药 靶向制剂 皮肤 药物相关性副作用和不良反应 综述

2024

实用皮肤病学杂志
中国人民解放军北京军区总医院

实用皮肤病学杂志

CSTPCD
影响因子:0.637
ISSN:1674-1293
年,卷(期):2024.17(6)