Objective To investigate the potential relationship between fibrin degradation product(FDP)levels and the development of biliary complications(BC)after liver transplantation,and to summarize the risk factors associated with the development of BC.Methods A retrospective cohort study was conducted in patients undergoing liver transplantation from January 2015 to July 2022 in the Southwest Hospital,Army Medical University and Sichuan Provincial People's Hospital.Demographic data,clinical indicators,and prognostic follow-up information of patients were analyzed.Overlap weighting(OW)was used to reduce bias.Receiver operating characteristic(ROC)curves were applied to define the cutoff value of FDP.The value divided patients into high-and low-FDP groups.Logistic regression identified risk factors.Results A total number of 491 patients were enrolled,and 79(16.1％)suffered from BC.Multivariable logistic regression revealed that FDP＞10.65 mg/L and MELD score＞15 were associated with BCs after OW.Conclusion High FDP had significant effect on the risk of BC occurrence and FDP＞10.65 mg/L was an independent risk factor for BC.
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