Objective To observe the effects of metronomic capecitabine(CAP)on immune cells and rejection in acute liver transplant rejection in rats,and to explore its immunosuppressive effect.Methods A rat liver transplantation acute rejection model was established and randomly divided into a control group(CON group),a metronomic capecitabine group(CAP group),and a metronomic capecitabine+tacrolimus(Tac)group(CAP+Tac group).Venous blood was collected on the 1st,3rd,and 7th day after liver transplantation,and enzyme-linked immunosorbent assay(ELISA)was used to detect IL-2 and IFN-γ concentrations,the trends of changes and correlations of IL-2 and IFN-γ between groups.Results Compare to the CON group,the concentration of serum IL-2 and IFN-γ gradually decreased in the CAP and CAP+Tac groups on the 1st,3rd,and 7th day after transplantation,and there was a statistically significant difference between the these two groups and the CON group(P＜0.05).Conclusion The metronomic capecitabine can reduce peripheral blood IL-2 and IFN-γ during acute rejection of liver transplantation in rats,it has potential immunosuppressive effects.
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