Objective Acute and severe liver failure progress rapidly with an extremely high mortality,while timely liver transplantation can save the patient's life.Due to the shortage of donors,patients often cannot match a suitable liver in time.Through the application of ABO-incompatible liver transplantation,the situation of liver shortage can be alleviated to a certain extent.Methods ABO-incompatible liver transplantation was performed on 3 patients with acute and severe liver failure.By adopting appropriate pretreatment methods,the postoperative complications and survival of the patients were observed.Results None of the 3 patients had acute rejection after the operation.Two patients survived for a long term.Among them,1 patient had biliary complications in the early stage and was treated in time,and 1 patient died due to severe infection.Conclusion For patients with acute and severe liver failure,emergency ABO-incompatible liver transplantation can also achieve good results.