Objective To evaluate the clinical outcomes of ABO-incompatible(ABOi)versus ABO-compatible/identical liver transplantation in pediatric patients.Methods This study conducted a retrospective analysis of clinical data from 49 pediatric patients who underwent liver transplantation at Hunan Children's Hospital between May 23,2017,and April 30,2023.Patients were divided into the ABOi group(8 cases)and the non-ABOi group(41 cases)based on ABO blood type compatibility between donors and recipients.The study compared pre-operative scores,transplantation waiting times,urgency levels on the waiting list,postoperative complications,and survival rates between the two groups.Results Pre-operative PELD scores and urgency levels on the waiting list were significantly higher in the ABOi group compared to the non-ABOi group.However,there was no significant difference in postoperative complications and survival rates between the two groups(P＞0.05).The comparison of post-transplant survival rates between the ABOi and non-ABOi groups also showed no significant difference(P＞0.05).Conclusion This study supports the use of ABOi-LT as an effective strategy to expand the donor pool for pediatric liver transplantation,especially for patients with high urgency levels.
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