盐酸氟桂利嗪与普瑞巴林治疗偏头痛的疗效分析
The effectiveness analysis of flunarizine hydrochloride combined with pregabalin in the treatment of overuseheadache
李祥1
作者信息
- 1. 277800 山东省枣庄市立医院药剂科
- 折叠
摘要
目的 探讨盐酸氟桂利嗪联合普瑞巴林对于药物过度使用所致偏头痛的疗效.方法 对2011年5月-2013年2月在枣庄市立医院门诊或住院收治的70例偏头痛患者给予普瑞巴林及盐酸氟桂利嗪治疗,比较治疗前后患者的头痛情况(包括发作频率、疼痛时间、VAS疼痛评分)、伴随症状(包括恶心、呕吐等)、生存质量(SF-36健康调查量表)等指标.结果 治疗4周后,患者的发作频率、头痛持续时间、VAS疼痛评分均显著低于治疗前水平,有统计学意义(P＜0.01);治疗后伴随有恶心呕吐症状的患者数量小于治疗前,有统计学意义(P＜0.05);治疗后患者的SF-36各因子水平均高于治疗前,有统计学意义(P均＜0.01).结论 盐酸氟桂利嗪联合普瑞巴林对于药物使用过度所致头痛患者的头痛、伴随症状及生存质量均有着显著的疗效.
Abstract
Objective Our retrospective study was aimed to analyze the effectiveness of flunarizine hydrochloride combined with pregabalin in the treatment of medication-overuseheadache.Methods 70 cases of patients with medicationoveruseheadache our hospital from may 2011 to February 2013 were received the treatment of flunarizine hydrochloride combined with pregabalinat was retrospectivelyanalyzed.The headache,simultaneous phenomenon and quality of life after treatment were analyzed with those before treatment.Results After 4 weeks of treatment,patients with seizures,headache duration,VAS pain scores were significantly lower than the level before treatment,there was statistically significant (P ＜0.01) ;the number of patients with symptoms of nausea and vomiting after treatment was less than before treatment,there was statistically significant (P ＜ 0.05) ; each factor of SF-36 level after treatment was higher than before treatment,there was statistical significance (P ＜ 0.01).Conclusion The treatment of flunarizine hydrochloride combined with pregabalin had a significant effect in the headache,simultaneous phenomenon and quality of life.
关键词
盐酸氟桂利嗪/普瑞巴林/偏头痛Key words
Flunarizine Hydrochloride/Pregabalin/Migraine引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据